Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil side effects Is plaquenil processed through the liver Can taking plaquenil cause weight loss RA is a systemic autoimmune disease in which the immune system attacks the joints and can affect other parts of the body.1 Several drugs to treat RA -- biologics Enbrel, Humira, etc. and DMARDS Plaquenil, methotrexate suppress the immune system.2 Suppressing the immune system helps slow or prevent damage to joints and other body systems. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Methotrexate may take longer to become effective, but USUALLY, it will take effective within the time frame you're looking at. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Can i take plaquenil and methotrexate together Plaquenil Oral Interactions with Other Medication, Combination therapy with methotrexate and. Early plaquenil visual fieldMacular oct plaquenil toxicity Does anyone know if hydroxychloroquine and methotrexate can cause weight loss day, been taking for over a year now but although it helps with some of the pain. I have to have steroid. Does anyone take methotrexate and hydroxychloroquine.. Methotrexate or Plaquenil? DailyStrength. Is It Safe To Take Turmeric / Curcumin With Arthritis.. Drug interactions are reported among people who take Plaquenil and Naproxen together. This study is created by eHealthMe based on reports of 1,166 people who take Plaquenil and Naproxen from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Can I still take vitamin supplements while on methotrexate? Q I take plaquenil and methotrexate for my rheumatoid arthritis, and folic acid. My rheumatology clinic has suggested not taking vitamin supplements as it's not known if they'll react with methotrexate and stop it working. View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more. Methotrexate Remove Methotrexate from your drug comparison. Plaquenil Remove Plaquenil from your drug comparison. View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more.