Risk of plaquenil retinopathy

Discussion in 'Canada Drugs Online' started by vitset, 28-Feb-2020.

  1. redbadcat Moderator

    Risk of plaquenil retinopathy


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Risk Factors. There are risk factors which may increase the likelihood of an individual in developing symptoms of Plaquenil toxicity 1. Dosage. The amount of drug the patient takes play a big role in increasing the risk for toxicity. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Other risk factors include Obesity; Duration of use cumulative dose Renal or hepatic functional impairment. Compromised kidney and/or liver function can lead to increased accumulation of hydroxychloroquine in the tissues. Age over 60 years. Hydroxychloroquine is a commonly used medication for rheumatoid arthritis, systemic lupus erythematosus, discoid lupus, Sjögren syndrome, juvenile idiopathic arthritis, other mixed connective tissue autoimmune conditions, non-small cell lung cancer, and graft-versus-host disease GVHD, to name a few.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Risk of plaquenil retinopathy

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  7. Jan 01, 2020 Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. Plaquenil is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. Limitations of Use in Malaria • Plaquenil is not recommended for the treatment of complicated malaria.

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    The risk may be much higher because retinopathy can be detected earlier when using more sensitive screening techniques. OBJECTIVES To reassess the prevalence of and risk factors for hydroxychloroquine retinal toxicity and to determine dosage levels that facilitate safe use of the drug. Marmor MF, Kellner U, Lai TYY, Melles RB, Mieler WF, for the American Academy of Ophthalmology. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy 2016 revision. Ophthalmology 2016;186-1394. Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. Hydroxychloroquine retinopathy. It is known that some people who take. hydroxychloroquine for more than five years and/or in high doses are at increased risk of. damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as. retinal toxicity or retinopathy.

     
  8. Sergoffff Moderator

    Almost immediately after Pfizer and Novartis provided evidence that chloroquine (used in several chemotherapy regimes) doesn’t do what people thought, another drug company (Astra Zeneca, along with coworkers at Dundee) is out with a paper suggesting what it might be doing instead. Definition of chloroquine - NCI Drug Dictionary - National Cancer Institute Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy. Chloroquine Indications, Side Effects, Warnings -
     
  9. DeeKey Guest

    Relapsed Hydroxychloroquine Induced Thrombocytopenia in. Although considered to be a safe treatment, side effects have been documented. An uncommon side effect is thrombocytopenia. In order to establish the diagnosis of thrombocytopenia secondary to Hydroxychloroquine, non-pharmacological causes must be ruled out and it is necessary to determine a recurrence after re-exposure to the drug.

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  10. Drug-Induced Urinary Incontinence - U. S. Pharmacist Aug 20, 2014 Hydroxychloroquine Hydroxychloroquine has recently been identified as an agent that can induce urinary incontinence. There is currently only one report supporting this finding. There is currently only one report supporting this finding.

    Drug-Induced Hyperkalemia High Potassium Levels