The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Hydroxychloroquine and phototherapy combination morphea Plaquenil charting and oct Crest plaquenil I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Methotrexate vs hydroxychloroquine Clinical efficacy and safety of methotrexate versus hydroxychloroquine., Methotrexate and plaquenil - How soon do effects of plaquenil takePlaquenil help payingChloroquine dreamsCan plaquenil make psoriatic arthritis worse Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Which would you pick and why? - Plaquenil or Methotrexate. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Methotrexate vs Plaquenil? -. Plaquenil is one of the firs line drugs and may or may not have side effects. MTX is more of a "chemo" medication and may or may not have side effects. I would encourage you to look at quality of life issues and go slowly if you are not in a hurry to squelch all of the discomfort of RA. The mean age of the patients at diagnosis was almost identically distributed between methotrexate and hydroxychloroquine group 41.7±12.2 vs. 42.9±9.2 years. In patients with rheumatoid arthritis, combination therapy with methotrexate, sulfasalazine, and hydroxychloroquine is more effective than either methotrexate alone or a combination of.