But there also has to be something negative going on if it's making my hair fall out! mshistory - I know what you're saying is ALL true. I won't let things go to long like this, but I am hoping this is just some sort of rebound effect and that things will level off. I need to find a new one, but with 2 small kids and work full time, who has the time?! like i said i have super thick hair so i still have have a good amount but its def not super super thick like it once was. for those of you losing hair loss-lets be like Dolly Parton and all these other stars and wear wigs! It was making me feel better in other ways -no doubt. As for the psychologist, I did try that over the summer, but was not impressed by the one I was going to. If you remember, most wait at least 3 months before they even see any improvement. i lost a bunch of hair the 1st 4 months and now it has steadied off... along with the extreme dry patchy skin that bleads and all my lovely knew wrinkles along my eyes from doing warm compresses , massage and drops!!! this disease sure takes a toll52 yr old Sj S, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) Ig G def., Cushing's, Asthma, Gastroparesis. Plaquenil aps pregnancy Hydroxychloroquine sulfate weight gain 4 aminoquinolines chloroquine Is plaquenil a sulfa drug Hydroxychloroquine is taken orally, and rapidly absorbed and metabolized by the liver. It is highly tissue bound and concentrates in melanin-rich pigments like the retina. It is excreted unchanged in the urine, and has a half-life of 45 days. Mechanism Hydroxychloroquine is thought to improve symptoms of systemic diseases by preventing. Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours. I thought methotrexate was stronger and had harder side effects??? Being 32 and feeling like I'm way too young to be dealing with any of this but trying to find my way through it BTW, seeing a psychiatrist and dealing with my depression and anxiety seriously saved my life. And your hair is growing back even while you're still on 200 a day? I wonder if what you're noticing is really the change in dose. You need to decided what is more important..or health.52 yr old Sj S, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) Ig G def., Cushing's, Asthma, Gastroparesis. Meds: IVIG & pre-meds, Arixtra, Aspirin, Plaquenil, Cardizem, Toprol XL, Domperidone, Nexium, Midodrine, Symbicort, Fentanyl, Percocet, Zofranthats the hard part---you never know.. If you feel really overwhelmed by all of this, it might be something to consider. now i still have quite a bit of hair but plaquenil made me lose a lot.. I'm wondering if 400 a day is just too much for some of us to handle? I say this because Plaquenil has a chemical half-life of 30-60 days (you can confirm this on wiki or RX info on the drug)--so it takes a LONG time to get out of your system..long for you to notice changes in days. whenever i take something new i think i get a weird side effect--but then again could it just be part of a flare...ughhhhh.. Hydroxychloroquine long half life Hydroxychloroquine An old drug with new relevance., Chloroquine and Hydroxychloroquine - Life in the Fast Lane Plaquenil sun spotsOct eye test plaquenilWhat does plaquenil do for arthritis Hydroxychloroquine is a DMARD. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Given the long half-life of hydroxychloroquine and the previously documented within day variations of less than 8% this was considered appropriate. All patients in the cohort were prescribed hydroxychloroquine not to exceed a dose of 6.5 mg per kilogram. The maximum daily dose prescribed is 400 mg. Both hydroxychloroquine and chloroquine have a large volume distribution and a long half-life, consistent with their slow onset of action and prolonged effects after drug discontinuation. Note hydroxycloroquine €“ has a long half-life 32€“56 days in blood and a large volume of distribution. In other words, the max time required to be totally out of the blood may be up to 112 days! Source & Cost. Other Name Plaquenil, etc. Can be ordered from pharmacy including online pharmacies such as this one. Here you have to say.