Chloroquine lysosomal membrane permeabilization

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  1. Sidjoo User

    Chloroquine lysosomal membrane permeabilization

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    Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin mTOR-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog. Sironi J1, Aranda E1, Nordstrøm LU1, Schwartz EL2. Transcription factor EB TFEB is a master transcriptional regulator playing a key role in lysosomal biogenesis, autophagy and lysosomal exocytosis. TFEB activity is inhibited following its phosphorylation by mammalian target of rapamycin complex 1 mTORC1 on the surface of the lysosome. Chloroquine induces permeabilization of lysosomal membranes As a lysosomotropic agent, CQ can rapidly diffuse into cells and been trapped in lysosomes. 17 We first labeled lysosomes with LysoTracker red DND-99 and monitored morphological changes of lysosomes associated with CQ treatment.

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    Chloroquine lysosomal membrane permeabilization

    PDF Modulating lysosomal function through lysosome., Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization.

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  4. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics ciprofloxacin CPX or norfloxacin NFX. CPX or NFX plus UV light NFX* induce lysosomal membrane permeabilization LMP, as detected by the release of cathepsins from lysosomes.

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    • Abstract 3511 Chloroquine-induced lysosomal membrane permeabilization..

    Autophagy and lysosomal cholesterol and permeabilization assays. Primary mouse hepatocytes PMH were incubated with rapamycin 2 μM with or without chloroquine 50 μM to examine autophagic flux. In some cases, PMH were incubated with chloroquine and brefeldin A to block autophagy and examine the impact on ER stress. Chloroquine is a lysosomotropic agent that triggers destabilization of the lysosomal membrane in various tumor cells. In one study chloroquine was used to restore sensitivity to cisplatin in refractory non-small-cell lung cancer cells 82. Autophagy, endoplasmic reticulum ER stress and lysosomal membrane permeabilization LMP were determined in ASMase −/− mice fed a HFD. The impact of pharmacological ASMase inhibition on NASH was analyzed in wild type mice fed a HFD.

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    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy. Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings.
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    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil comes in 200 milligram mg tablets that are taken by mouth. To prevent malaria in adults, two tablets are typically taken once a week, on the same day each week.

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    Application of Liposomes Nanoparticles in the Treatment of. Moreover, the ability to increase the doses of chloroquine per injection after liposome encapsulation allowed successful treatment of infection with chloroquine resistant P. berghei which could be cured by a seven-day course with the maximum tolerable dose of free chloroquine 35.

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