Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine mode of action Side effects of starting plaquenil Chloroquine autophagy inhibitor TRAVEL TO AREAS WITH CHLOROQUINE-RESISTANT MALARIA. Chloroquine-resistant P. falciparum is found in all parts of the world except the Caribbean and countries west of the Panama Canal. Although chloroquine-resistant P. falciparum predominates in Africa, it is found in combination with chloroquine-sensitive P. vivax malaria in South America and Asia. People with falciparum malaria may need to be monitored in the intensive care unit of a hospital during the first days of treatment because the disease can cause breathing failure, coma and kidney failure. For pregnant women, chloroquine is the preferred treatment for malaria. Possible outcomes in individuals treated with chloroquine for Plasmodium falciparum malaria. Infections with chloroquine-resistant parasites may persist or clear after treatment, depending on the status of preexisting malaria immunity premunition. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine-resistant malaria may be treated with __________ Chloroquine - Wikipedia, Malaria Guide Causes, Symptoms and Treatment Options Chloroquine plus proguanil side effectsPlaquenil and dementiaPlaquenil retinaIs hydroxychloroquine an immunosuppressant drug The combination of atovaquone and proguanil is highly effective for the prophylaxis and treatment of chloroquine-resistant malaria. Artemether/lumefantrine inhibits CYP2D6 and can raise the levels of drugs that are substrates for this enzyme, including imipramine. Artesunate is an investigational drug used for severe malaria. Chapter 98 Antiprotozoal Drugs I Antimalarial Agents.. Chloroquine-Resistant Malaria The Journal of Infectious.. Effective treatment with a tetrandrine/chloroquine combination for.. Treatment of Uncomplicated Malaria Plasmodium falciparum or Species Not Identified – Acquired in Areas Without Chloroquine Resistance. For Plasmodium falciparum infections acquired in areas without chloroquine-resistant strains, which include Central America west of the Panama Canal, Haiti, and the Dominican Republic, patients can be treated with oral chloroquine. Guidelines for Treatment of Malaria in the United States. Regimens used to treat chloroquine -resistant infections may also be used if chloroquine and hydroxychloroquine are not available. Note that if treating. chloroquine-resistant malaria species. Artemether-lumefantrine Coartem™ Chloroquine-resistant malaria is exactly what it sounds like—particular types of malaria which are not cured by treatment with chloroquine. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s.