Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. Hydroxychloroquine hyperpigmentation Leukemia and plaquenil Leukopenia, which frequently occurs in patients with systemic lupus erythematosus, is usually not severe i.e. white blood cell count of less than 1,000 × 10 3 per mm 3 1.0 × 10 9 per L and rarely requires treatment. Thrombocytopenia, if stable, and if the platelet count remains above 50,000 × 10 3 per mm 3. Oral thalidomide has increasingly been accepted as a treatment for cutaneous lupus erythematosus CLE, including DLE lesions, that have not responded to other treatments. Stevens RJ, Andujar C, Edwards CJ, et al. Thalidomide in the treatment of the cutaneous manifestations of lupus erythematosus experience in sixteen consecutive patients. Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Treatment of discoid lupus erythematosus with chloroquine An update on the use of hydroxychloroquine in cutaneous., Discoid lupus erythematosus - Treatment algorithm BMJ. Plaquenil drug rashDefine hydroxychloroquineChloroquine pills given to troops in viet nameOct of plaquenil toxicityHow many hours does hydroxychloroquine work on arthritis Two cases of subacute disseminated lupus erythematosus were also treated with chloroquine sulphate with no satis-factory clinical response. Summary and Conclusions Eighteen cases of chronic discoid lupus erythematosus were treated with chloroquine sulphate by mouth. The results are tabulated and discussed. MEDICAL CHLOROQUIE SULPHATE TREATMENT OF CHRONIC DISCOID.. Systematic administration of chloroquine in discoid lupus.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. User Reviews for Plaquenil to treat Systemic Lupus Erythematosus. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Discoid lupus erythematosus DLE is a form of lupus that mainly affects your skin. DLE is different from systemic lupus erythematosus SLE, the most common form of lupus, which can affect any part of the body. Aug 21, 2018 Hydroxychloroquine is the first-line systemic agent for discoid lupus erythematosus DLE, whereas chloroquine is considered second-line antimalarial therapy in the United States.