Retinal toxicity associated with hydroxychloroquine and chloroquine

Discussion in 'Chloroquine' started by long3r, 22-Feb-2020.

  1. A.TIX Guest

    Retinal toxicity associated with hydroxychloroquine and chloroquine


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Quinine is an antimalarial associated with a distinct toxicity from that of chloroquine and hydroxychloroquine. Quinine is used for benign nocturnal muscle cramps and may cause toxicity with acute overdose. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Retinal toxicity associated with hydroxychloroquine and chloroquine

    Recommendations on Screening for Chloroquine and., Retinal toxicity associated with chronic exposure to.

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  6. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible.

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    The Risk of Retinal Toxicity with Plaquenil. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. How does chloroquine and hydroxychloroquine cause retinal toxicity? Both medications bind to melanin in the RPE, which may concentrate or prolong their effects. Although the incidence of toxicity is low, it is of serious concern because associated vision loss rarely recovers and may even progress after the drug is discontinued. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.

     
  7. adventurer User

    Hydroxychloroquine belongs to a group of medicines known as antimalarials. Went from Generic Plaquenil to Brand Name Plaquenil due to. Generic Plaquenil Availability - Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
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  9. Toss Moderator

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. To treat rheumatoid arthritis, the dosage is higher, with one to three tablets typically taken once a day. If you miss a dose of Plaquenil, take it as soon as your remember.

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