Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil and stomach ulcers Sulfasalazine and plaquenil This phase I clinical trial studies the side effects and best dose of oncolytic HSV-1 rQNestin34.5v.2 rQNestin34.5v.2 with or without cyclophosphamide in treating patients with malignant glioma that has come back recurrent. rQNestin34.5v.2 is a drug made from the herpes simplex virus type I, and if it is effective, may spread to a tumor cell, kill it, and then make a copy of itself and spread again. Chloroquine has the potential of opening new frontiers in the treatment of glial neoplasms and should be tested in large clinical trials. Glioblastoma multiforme GBM is 1 of the most aggressive neoplasms of the central nervous system. GBMs usually follow an aggressive course, and patients have a median survival of 8 months to 10 months. Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies Neurosurgical Focus 142 February, 2003 and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine clinical trials glioma Study protocol of a phase IB/II clinical trial of metformin and., Chloroquine in glioblastoma—New horizons for an old drug. Chloroquine phosphate 250 mg side effectsTeva-chloroquine effets secondairesPlaquenil and alcohol side effects The Addition of Chloroquine to Chemoradiation for Glioblastoma, Study Purpose Glioblastomas GBM are the most common type of primary brain tumors with an annual incidence of approximately 500 patients in the Netherlands. The Addition of Chloroquine to Chemoradiation for Glioblastoma.. Chloroquine for Treatment of Glioblastoma Multiforme - Full.. Frontiers Re-purposing Chloroquine for Glioblastoma.. Investigators at the University of Colorado are now reporting that adding the anti- malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize. Chloroquine, in conjunction with other treatments, may prolong survival in patients with glioblastoma multiforme. Larger clinical trials are needed. —The Editors Article Chloroquine for Glioblastoma Multiforme 338 7 March 2006 Annals of Internal Medicine Volume 144 • Number 5 Chloroquine, in conjunction with other treatments, may prolong survival in patients with glioblastoma multiforme. Larger clinical trials are needed.