I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Valtrex and plaquenil Chloroquine off target effects Chloroquine phosphate ich Jun 11, 2013 For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Fatigue is part of malaria, which is the normal use of this medication. Here are the side effects be sure your doctor looks at this. Get emergency medical help if you have any of these signs of an allergic reaction while taking hydroxychloroquine hives ; difficulty breathing; swelling of your face, lips, tongue, or throat. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Plaquenil sjogren's fatigue Plaquenil and Depression/Anxiety - Sjogren's Syndrome Support, Hydroxychloroquine - thigh muscle weakness? Chloroquine 750 mg Basic fatigue 1. This is the inherent fatigue that I attribute to the inflammatory, autoimmune nature of Sjögren’s. It's with me all the time. It differs from normal fatigue in that you don't have to do anything to deserve it. It can vary from day to day but is always there. Types of Sjogren's Fatigue. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Hydroxychloroquine User Reviews for Sjogren's. -. Fatigue Fatigue is most effectively managed with self-care measures and exercise. Exercise provides similar benefit to reduce fatigue in Sjögren’s patients as was seen for those with RA, SLE or Multiple Sclerosis. Systemic Manifestations in Sjögren’s Patients Sjogren's SHOW-grins syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. I was diagnosed with Sjogrens Syndrome 3 months ago. I also have rheumatoid Arthritis and Hashimotos. My rheumatologist prescribed Plaquenil in hopes to control all 3 conditions. I would say that Plaquenil has basically given me my life back. I suffer from debilitating joint pain, fatigue, brain fog and extreme anxiety.