Sorry, there has been an issue processing your request. Alternatively, head back to the home page and see how we're leading the fight against the pain of Arthritis. Hello hope everyone is welljust a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.i'm not expecting it to work over night but soon hopefullyi am still in so much pain everyday and hoping for some relieve soon. Plaquenil retina Does taking plaquenil cause hair loss How quickly does eye damage progress hydroxychloroquine How much does generic plaquenil cost Take good care of your mouth to help prevent mouth sores. Use a soft toothbrush and a mouthwash. Avoid drinking alcohol or keep alcohol intake to a minimum while taking methotrexate. If you are a woman with child-bearing potential, you should always use a reliable form of contraception while you are taking methotrexate. I was on both for 2 years without a problem, I've stopped taking plaquenil but am still on 20mg methotrexate per week for closer to 3 years now without incident. Yes it's scary to begin with but when your quality of life slowly returns it's all worthwhile. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. (others may do) and i then can get benefits till i find a job i can do with the ra(i am not doing this just for benefits, i hope people understand that) I have now been on Plaq for just over three years and MTX for just under three years. Also had to have an occupational health meeting today for my job as not worked for 6 months now and hoping they make me redundant as i can't work as a waitress with ra due to pain and flares in my opinion. Why take hydroxychloroquine with methotrexate Does anyone know if hydroxychloroquine. - HealthUnlocked, Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma. Psoriasis hydroxychloroquine OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. Combination therapy with methotrexate and hydroxychloroquine.. Which would you pick and why? - Plaquenil or Methotrexate. How Does Methotrexate Treat Rheumatoid Arthritis? - WebMD. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. That’s not to suggest that taking methotrexate is risk-free. But doctors who prescribe methotrexate for arthritis say that following a few simple steps can make it even safer to use and reduce potential side effects. How Methotrexate Works. Understanding how methotrexate works helps explain why it can cause unwanted effects. Do not take more or less of it or take it more often than prescribed by your doctor. If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor.