Listing a study does not mean it has been evaluated by the U. Hydroxychloroquine, which blocks autophagy, may slow the growth of and possibly kill prostate cancer cells. This phase II trial studies how well hydroxychloroquine works in treating patients with previously treated prostate cancer. What is plaquenil taken for Hydroxychloroquine pronounce Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. Prostate cancer cells lack zinc and taking zinc or zinc citrate does not mean that it will reach these research show that zinc ionophores increase zinc uptake having anti cancer effects. Human Prostate Cancer is a ZIP1-Deficient Malignancy that could be Effectively Treated with a Zinc Ionophore Clioquinol Approach Once cohort A completed, the dose of hydroxychloroquine will then be increased to 600mg per day (200mg three times per day)(cohort B). Hydroxychloroquine will be taken at a dose of 200 mg twice per day in the first 27 patients (cohort A). Chloroquine prostate cancer Chloroquine - Cancer Therapy Advisor, Chloroquine Is a Zinc Ionophore - PubMed Central PMC Hydroxychloroquine cause weight lossTrametinib and hydroxychloroquineReactions to plaquenil Non-castrating treatments for BCR and metastatic prostate cancer are an area of unmet need. The aim of this study is to assess the tolerability, safety and efficacy of hydroxychloroquine in combination with itraconazole as a strategy to delay time to ADT commencement in men with BCR prostate cancer. Phase I/II Study of Hydroxychloroquine With Itraconazole.. Is hydroxychloroquine a zinc ionophore? - Advanced Prostate.. Dissecting pharmacological effects of chloroquine in.. Autophagy as a modulator and target in prostate cancer 2014 Nature Review Urology, 11, pgs. 508-514 Jason M. Farrow, Joy C. Yang & Christopher P. Evans University of California, Davis Autophagy, or 'self-eating', is an adaptive process that enables cells to cope with metabolic, toxic, and even infectious stressors. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the.