One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hg wang chloroquine Images early plaquenil toxicity fundus autoflurouecense Can taking plaquenil cause weight loss Sep 18, 2017 The Risk of Hydroxychloroquine Toxic Retinopathy and Its Risk Factors in the Treatment of Rheumatic Diseases A Systematic Review April Jorge 1, Sharan K. Rai 2 and Hyon K. Choi 2, 1 Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2 Division of Rheumatology, Allergy, and Immunology. And significant visual field defects consistent with hydroxychloroquine retinopathy, but without evidence of structural defects on SD-OCT or FAF may be considered for multifocal electroretinography. Screening may be commenced before five years of therapy if additional risk factors exist e.g. very high dose of drug therapy, Plaquenil hydroxycholoroquine is a medication used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions. It is very effective and the risk of damage to the eye is very low the first five years if the patient is receiving the recommended dose and does not have special risk factors like kidney damage. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil retinopathy risk factors Risk Factors for Hydroxychloroquine and Chloroquine., Hydroxychloroquine and Chloroquine Retinopathy. What is hydroxychloroquine 200mg forPlaquenil side effects stomach painCan chloroquine cause death Mar 10, 2017 The risk factors detailed below are recognised to increase the risk of HCQ retinopathy. The sum of risk factors can provide an estimation of risk for a given individual. 40 Some risk factors are. Hydroxychloroquine retinopathy Eye. PLAQUENIL MONITORING — Ocean Opthalmology. The Risk of Toxic Retinopathy in Patients on Long-term.. The risk factors reported by the American Academy of the Ophthalmology AAO were compared between patients with n = 5 and without toxicity n = 26 findings. Risk score was calculated for each patient. Risk factors for retinopathy normal daily doses range 75-300mg toxicity has been reported with doses of 1200 to 2400 mg/day for 1 to 2 years. Mechanism - Inhibition of retinal enzymes and phototoxicity have been suggested as possible causes of the retinal degeneration. Melles R, Marmor M. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophthalmol. 2014;132121453-60. 6. Michaelides M, Niam H, Stover P, et al. Retinal toxicity associated with hydroxychloroquine and chloroquine risk factors, screening, and progression despite cessation of therapy.