I am not shocked about having it just being diagnosed with it. I have seen my rheumatologist for five years and I guess she just thought it was time. Plaquenil effects on diarrhea Does hydroxychloroquine Plaquenil for relapsing polychondritis Hydroxychloroquine 200mg Hearing Loss; Heart Failure; Hives; Increased Sensitivity Of The Skin To The Sun; Low Blood Counts Due To Bone Marrow Failure; Low Blood Sugar; Low Levels Of A Type Of White Blood Cell Called. GOOD NEWS hair loss & weight gain are NOT associated with Plaquenil. The other two classes are steroids & immunosuppressants, used where major organs are compromised. These types have a huge range of possible side effects---which is possibly what you were thinking of when you cited weight gain & hair loss. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. In this case, the cause of loss f appetite and weight loss has to be found. She tried to put me on it two years ago even before she diagnosed me because she has always suspected lupus. Anyway, I'm scared to death to take plaquenil but I know that I probably should. Does plaquenil cause weight loss or weight gain Rx Side Effects New Plaquenil Guidelines and More - American., Want to know good stuff about plaquenil - HealthBoards Does plaquenil cause acne Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil and loss of appetite - Lupus - MedHelp. Plaquenil and weight loss DailyStrength. Plaquenil hydroxychloroquine can cause some loss in appetite, but 30 pounds in three months is extreme and needs a thorough investigation. Plaquenil can cause loss of appetite and I agree that losing weight at this rate and suffering diarrhea is not healthy and might mean you become ill nourished and dehydrated. Yes, I did and I couldn't gain weight while on it, even while I was scarfing down tons of junk food TRYING to gain weight for the longest time, I was about 96 pounds and I'm nearly 5'4". I've been off the Plaquenil for 3 weeks now, and I've already gained two or three pounds - more weight than I have been able to gain in the past year on.