Curvilinear bodies hydroxychloroquine cardiomyopathy

Discussion in 'Hydroxychloroquine Sulfate' started by Sistem, 20-Mar-2020.

  1. SEOGOOD Well-Known Member

    Curvilinear bodies hydroxychloroquine cardiomyopathy


    However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case of twin sisters who both suffered from systemic lupus erythematosus (SLE) and HCQ-induced cardiomyopathy presenting with decompensated heart failure (HF), suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy.

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    Hydroxychloroquine and chloroquine are often used for long-term treatment of rheumatic diseases and for malaria prophylaxis. Hydroxychloroquine- and chloroquine-induced cardiomyopathy have well-described microscopic features, with the classic electron microscopic findings of myelin figures myeloid bodies. Biopsy of curvilinear body formation. In this report, we describe a patient with rheumatoid arthritis and respiratory failure associated with proximal myop-athy secondary to HCQ. Characteristic changes on muscle biopsy were present. Patients treated with HCQ in whom proximal myopathy, neuropathy, or cardiomyopathy develop should be evaluated for possible HCQ toxicity. Clinicians should be aware of Hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease.

    Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use (1). Hydroxychloroquine (HCQ) is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases (1).

    Curvilinear bodies hydroxychloroquine cardiomyopathy

    Hydroxychloroquine Induced Cardiotoxicity A Rare., Hydroxychloroquine-Induced Toxic Myopathy Causing Respiratory.

  2. Plaquenil and photosensitivity
  3. Patients with systemic lupus erythematosus SLE can present with multiple cardiovascular pathologies, including pulmonary hypertension, valvular disease, pericarditis, myocarditis, and premature atherosclerosis. SLE medications can also cause cardiovascular side effects. We present a patient who developed a severe cardiomyopathy secondary to the hydroxychloroquine prescribed to treat her SLE.

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    Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy key diagnostic features and literature review. Curvilinear bodies in particular appear to be the most specific histological indicator of antimalarial-related cardiotoxicity and these structures are not seen in differential diagnoses of some of. Jan 03, 2020 PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients Dibasic calcium phosphate USP, hypromellose USP, magnesium stearate NF, polyethylene glycol 400 NF, polysorbate 80 NF, corn starch, titanium dioxide USP, carnauba wax NF, shellac NF, black iron oxide NF. Cardiomyopathy related to antimalarial therapy with illustrative case report. Champion HC, Wigley FM, Halushka MK. New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy a report of 2 cases. Hum Pathol. 2007; 58–1863. Crossref Medline Google Scholar; 3. Jain D, Halushka MK. Cardiac pathology of.

     
  4. tpsystem User

    Hydroxychloroquine and chloroquine are medications traditionally prescribed to prevent or treat malaria infections. Malarone vs Plaquenil Comparison - Hydroxychloroquine Oral Route Before Using - Mayo Clinic Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert
     
  5. G-SHIK User

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Taking Plaquenil for Rheumatoid Arthritis Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus How Long Did It Take? Plaquenil - Scleroderma - Inspire
     
  6. Stargaser Moderator

    Chloroquine and Hydroxychloroquine Toxicity Chloroquine and hydroxychloroquine belong to the quinolone family. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. Initially, chloroquine was given for malaria prophylaxis and treatment.

    Chloroquine and Hydroxychloroquine Toxicity Practice.
     
  7. Device Guest

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.