However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case of twin sisters who both suffered from systemic lupus erythematosus (SLE) and HCQ-induced cardiomyopathy presenting with decompensated heart failure (HF), suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy. Weight loss taking hydroxychloroquine Plaquenil insert Hydroxychloroquine and chloroquine are often used for long-term treatment of rheumatic diseases and for malaria prophylaxis. Hydroxychloroquine- and chloroquine-induced cardiomyopathy have well-described microscopic features, with the classic electron microscopic findings of myelin figures myeloid bodies. Biopsy of curvilinear body formation. In this report, we describe a patient with rheumatoid arthritis and respiratory failure associated with proximal myop-athy secondary to HCQ. Characteristic changes on muscle biopsy were present. Patients treated with HCQ in whom proximal myopathy, neuropathy, or cardiomyopathy develop should be evaluated for possible HCQ toxicity. Clinicians should be aware of Hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease. Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use (1). Hydroxychloroquine (HCQ) is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases (1). Curvilinear bodies hydroxychloroquine cardiomyopathy Hydroxychloroquine Induced Cardiotoxicity A Rare., Hydroxychloroquine-Induced Toxic Myopathy Causing Respiratory. Plaquenil and photosensitivity Patients with systemic lupus erythematosus SLE can present with multiple cardiovascular pathologies, including pulmonary hypertension, valvular disease, pericarditis, myocarditis, and premature atherosclerosis. SLE medications can also cause cardiovascular side effects. We present a patient who developed a severe cardiomyopathy secondary to the hydroxychloroquine prescribed to treat her SLE. A Case of Heart Failure in a Patient With Systemic Lupus.. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Hydroxychloroquine-induced toxic myopathy causing respiratory.. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy key diagnostic features and literature review. Curvilinear bodies in particular appear to be the most specific histological indicator of antimalarial-related cardiotoxicity and these structures are not seen in differential diagnoses of some of. Jan 03, 2020 PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients Dibasic calcium phosphate USP, hypromellose USP, magnesium stearate NF, polyethylene glycol 400 NF, polysorbate 80 NF, corn starch, titanium dioxide USP, carnauba wax NF, shellac NF, black iron oxide NF. Cardiomyopathy related to antimalarial therapy with illustrative case report. Champion HC, Wigley FM, Halushka MK. New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy a report of 2 cases. Hum Pathol. 2007; 58–1863. Crossref Medline Google Scholar; 3. Jain D, Halushka MK. Cardiac pathology of.