Fundus autofluorescence hydroxychloroquine

Discussion in 'Hydroxychloroquine Sulfate' started by andreysa, 20-Mar-2020.

  1. framzik Well-Known Member

    Fundus autofluorescence hydroxychloroquine


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Fundus autofluorescence patterns in various stages of hydroxychloroquine retinopathy. Classic bull’s-eye maculopathy appearance A. As the RPE atrophies, the FAF intensity in the pericentral macula changes to a mottled, or speckled appearance B, and eventually coalesces into dark areas of absence of FAF signal once the cells have died C. Hydroxychloroquine HCQ has been used for therapy of rheumatologic disorders since the 1950s. SD-OCT, in combination with Humphrey’s visual field 10-2, as well as fundus autofluorescence and multifocal ERG in select patients, is critical for the early detection of HCQ retinopathy. Fundus autofluorescence FAF is a non-invasive imaging technique that detects fluorophores, naturally occurring molecules that absorb and emit light of specified wavelengths 1. To produce autofluorescence, a fluorophore absorbs a photon of the excitation wavelength, which elevates an electron to an excited, high energy state.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Fundus autofluorescence hydroxychloroquine

    Clinical applications of fundus autofluorescence in retinal., Expanded spectral domain-OCT findings in the early.

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  6. Hydroxychloroquine Retinopathy-Fundus Autofluorescence. Fundus autofluorescence image of a 46-year-old woman with systemic lupus erythematosus who had taken chloroquine for 17 years at a dosage of 500 mg/d. Based on her actual body weight, which was ideal, she had been overdosed at 8.8 mg/kg/d and had received a cumulative dose of 3102 g of hydroxychloroquine.

    • Hydroxychloroquine Retinopathy-Fundus Autofluorescence - The..
    • Clinical applications of fundus autofluorescence in..
    • Hydroxychloroquine retinopathy A review of imaging.

    To detect chloroquine toxicity, the American Academy of Ophthalmology recommends performing fundus examinations, 10-2 automated visual fields, and at least one objective test multifocal electroretinography mfERG, fundus autofluorescence imaging, or spectraldomain optical coherence tomography SD-OCT. 1 By contrast, Amsler grid testing. In the present day, the less toxic HCQ is used instead of chloroquine. The American Academy of Ophthalmology revised the screening guidelines in 2011 to include spectral domain-optical coherence tomography SD-OCT, fundus autofluorescence FAF, and multifocal ERG mfERG when available to assess the macula in patients taking HCQ. The new. To the Editor I was pleased to see pictures of hydroxychloroquine toxicity in the recent Ophthalmic Images,1 as a reminder that the problem still exists. However, some readers may draw an erroneous impression from the caption, which suggests that fundus autofluorescence may “be useful to determine.

     
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