While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Plaquenil and vascular system Chloroquine and sun exposure Malaria preventative chloroquine aralen May 07, 2019 Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. I have been on every med you can think of when it comes to trying to keep your lupus in remission. Plaquenil is not as "sweet" as you may think. Plaquenil is good as long as you have your lupus in remission. 12 replies. I am at the point where the pain and exhaustion are so miserable just let me feel good until it doesn't work and let. Oct 22, 2009 There are pros and cons for all of them and it's a matter of finding one that suits and one that doesn't give you any intolerable side effects. Make sure you take them on a full stomach. Your doc would help you work out which one might be best for you based on your individual circumstances. Good luck! It can decrease the pain and swelling of arthritis. Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). What if plaquenil doesn't work for lupus Hydroxychloroquine User Reviews for Systemic Lupus., Lupus Board Index how does plaquenil work How can you get hydroxychloroquineHydroxychloroquine pharmacotherapyPlaquenil leg swellingPlaquenil treatment sle How long does it take for plaquenil to work? I just started about 6 weeks ago, the rheum said it can take up to a year. Let me know how you are doing on it. Plaquenil - does it take long time to work? - Lupus - Inspire. If Plaquenil doesn't work. Lupus Forums at The Lupus Site. Plaquenil. A medication for Lupus. Apr 10, 2019 Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis. Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain.