Hydroxychloroquine-mediated retinopathy

Discussion in 'Northwest Pharmacy' started by Artix, 01-Mar-2020.

  1. WASP Well-Known Member

    Hydroxychloroquine-mediated retinopathy

    Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing.

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    Most cases of chloroquine retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 21 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 22 One study showed a 19% incidence of chloroquine retinopathy in. Chloroquine-induced keratopathy is limited to the corneal epithelium, where high concentrations of the drug are usually used. The retinopathy encountered with the prolonged use of chloroquine analogues is a much more serious clinical problem and can lead to irreversible damage to the retina and loss of vision. Megan B. Goodman, Ari Ziskind, Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy, African Vision and Eye Health, 2015, 74, 1CrossRef; 19 Junyeop Lee, Joo Yong Lee, Hydroxychloroquine Retinopathy, Journal of Rheumatic Diseases, 2015, 22, 3, 140CrossRef

    Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG).

    Hydroxychloroquine-mediated retinopathy

    Chloroquine - Wikipedia, Chloroquine analogues in drug discovery new directions of.

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  5. Hydroxychloroquine-Induced Myopathy. Article. In this regard, there is already a connection between thiamine deficiency and retinopathy in diabetic patients 30, and diabetic retinopathy can.

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    Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer - Full Text View. Early detection of hydroxychloroquine-induced retinopathy is known to prevent visual acuity loss and serious progression after the therapy is stopped, and these data suggest that screening should. The risk of hydroxychloroquine-mediated retinal toxicity is relatively low within the first 5–10 years of therapy when used at daily doses that do not exceed 5 mg/kg, typically 200–400 mg daily. 1 Risk is clearly a balance between daily dose and duration of use, but there are little data available on the degree to which highly elevated doses can accelerate toxicity.

  6. Zainiddin XenForo Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. PPT1 promotes tumor growth and is the. - Cancer Discovery Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Plaquenil Uses, Dosage & Side Effects -
  7. poetry_cin Moderator

    Malaria infection in pregnant women is associated with high risks of both maternal and perinatal morbidity and mortality. Safety of chloroquine in chemosuppression of malaria during. Chloroquine Phosphate - Usages, effets secondaires, Avis, Composition. Chloroquine Use During Pregnancy
  8. cthubec Well-Known Member

    Hydroxychloroquine Indications, Side Effects. - May 24, 2019 Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Hydroxychloroquine DermNet NZ
  9. Vefire Moderator

    Hydroxychloroquine Compared to Alternatives - Compare Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. Hydroxychloroquine Compared to Alternatives -

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