Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil ulcerative colitis How long does chloroquine stay in your system Is plaquenil covered by blue cross Is hydroxychloroquine a sulfa drug By 2/2010 things were so dim I could not see to shop in stores. I quit taking Plaquenil but the DR still said no toxicity. My eyes continued to get worst. In tears I went back in July he finally sent me to a retina specialist. You don't have to have Bulls eye damage to have toxicity Over weight women over 60 should beware of taking Plaquenil. Advanced hydroxychloroquine toxicity presents as a bullseye maculopathy. Since retinal toxicity is usually irreversible, early detection of retinal toxicity and cessation of the offending agent is the best treatment. Corneal toxicity presents as an intraepithelial deposition of the drug into the cornea, which rarely affects vision. The presence of bull’s-eye maculopathy indicates the disease has been progressing for years, resulting in foveal thinning and likely vision loss. 8 SD-OCT is a highly sensitive and reproducible imaging modality used in the detection of Plaquenil retinal toxicity. The preferential loss of photoreceptor IS/OS junction makes SD-OCT an ideal tool. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Plaquenil toxicity bull's eye maculopathy Plaquenil Toxicity - Bulls Eye Maculopathy - Retina., Hydroxychloroquine toxicity - EyeWiki Autofluorescence plaquenil toxicityPlaquenil visual field testingLose weight after plaquenilPlaquenil and eye floaters Bull’s eye maculopathy. A 55-year-old female who had been taking hydroxychloroquine for 10 years before the onset of symptoms. A Color fundus photos showing bull’s-eye maculopathy. B Fundus autofluorescence with central mottled. Retinal toxicity associated with chronic exposure to hydroxychloroquine.. How to Succeed in Plaquenil Screenings. Bull's-eye maculopathy due to hydroxychloroquine toxicity. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Torpedo maculopathy; Diagnosis Bull’s eye maculopathy presumed Hydroxychloroquine toxicity RELE Management Updated single-vision intermediate lenses were recommended for computer work in order to maximise the patient’s field of view. Although she has discontinued Plaquenil, a report identifying these adverse effects was sent to the. Plaquenil Toxicity - Bulls Eye Maculopathy 575 views 70-year-old woman with systemic Lupus erythematosus and clotting problems. She was on the Plaquenil for about eight years and then off the Plaquenil for the last eight years because she developed macular toxicity.