Why malaria becomes resistant to chloroquine

Discussion in 'Plaquenil' started by sergey11223, 02-Mar-2020.

  1. KRoN Moderator

    Why malaria becomes resistant to chloroquine


    Artemisinin Combination Therapies, or ACTs, are currently the frontline treatments against malaria. Although these treatments are working well in many parts of the world, there is serious concern that malaria parasites are once again developing widespread resistance to this vital treatment.

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    A In most parts of the world, falciparum malaria has become resistant to conventional treatment, such as chloroquine, sulfadoxine-pyrimethamine, and other antimalarial medicines used on their own. This is why WHO recommends that countries use a combination of drugs to fight malaria. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle to malaria control and elimination. The parasite has developed resistance to every anti-malarial drug introduced for wide-scale treatment. However, the spread of resistance may be reversible. Malawi was the first country to discontinue chloroquine use due to widespread resistance. Within a decade of the removal of.

    The cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. As the threat of antimalarial drug resistance grows, there is increasing pressure to sustain the efficacy of existing treatments, develop alternative treatments, as well putting in place preventative measures such as bednets.

    Why malaria becomes resistant to chloroquine

    Antimalarial drug resistance, CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and Deaths Be.

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    • Chloroquine Uses, Side Effects & Warnings -.

    Do not use Chloroquine phosphate tablets for the treatment of complicated malaria high-grade parasitemia and/or complications e.g. cerebral malaria or acute renal failure. Do not use Chloroquine phosphate tablets for malaria prophylaxis in areas where Chloroquine resistance occurs, Resistance to Chloroquine phosphate tablets is widespread in P. falciparum, and is reported in P.vivax see WARNINGS. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a. Malaria infection associated with travel. Center for Global Health Division of Parasitic Diseases and Malaria. Who can take chloroquine? Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant. women and nursing mothers. Who should not take chloroquine? People with psoriasis should not take.

     
  5. Michaelka XenForo Moderator

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  6. weisewolf Moderator

    Chloroquine phosphate REEF2REEF Saltwater and Reef Aquarium. Chloroquine phosphate Treats Ich Cryptocaryon irritans, Marine Velvet Disease Amyloodinium, Brooklynella hostilis & Uronema marinum. How To Treat - Chloroquine phosphate CP is a “new drug” that actually was widely used to control external protozoa in saltwater aquariums back in the 70s & 80s.

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  7. Mygen Well-Known Member

    Plaqunil rash - Hydroxychloroquine Plaquenil is one of the safest drugs in medicine. Serious side effects are rare & routine blood tests are not required. Allergy new skin rashes is unusual but it means ruling our future use. Commoner, usually mild, side effects are indigestion, ‘gurgly tummy’, diarrhoea & headache.

    Hydroxychloroquine Oral Uses, Side Effects, Interactions.