The cramping, cold sweats, and explosive diarrhea was unimaginable. Its my classic reaction to all new psych drugs and new antiseizure drugs, including neurontin. It is a pain in the you kno what, but I have to do what I have to do! I thought I was going to pass out the pain was so bad. Plaquenil itself I've never had an issue with, but there was a med I was given for a UTI that I didn't know was NOT supposed to be with food that gave me that kind of reaction. I wasn't too bad with Plaquenil until I doubled the dose a few weeks ago to 400mg. Plaquenil malaria prevention Quinine sulfate allergy is it okay to take plaquenil Plaquenil and effexor Chloroquine in lupus Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. Some antacids can make it harder for your body to absorb hydroxychloroquine. Hydroxychloroquine can cause serious liver or heart problems, especially if you use certain medicines at the same time. Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. Hopefully, it's like Lynwood said - a one time anomaly. I didn't think it was going to be like this though! I really have to shift the burden off my liver whenever I can. Love, Marji I am going on week three with the plaq and I have worked out a little routine. I did give myself a much needed cleanse though..... You might want to check the website it's a great drug interaction website that also checks some foods & seasonings Sorry you had that nasty episode, I bet it's a one-time combo of some kind that did you in. Then I had explosive diarrhea I've settled down a bit but about once a week I have a really bad blow out. But I'm starting to feel a lot better with my other symptoms, so a little digestive discomfort is worth it I suppose. Can hydroxychloroquine cause diarrhea Hydroxychloroquine Oral Uses, Side Effects, Interactions., Hydroxychloroquine - Side Effects, Dosage, Interactions. Plaquenil arthritis side effects RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Common and Rare Side Effects for Plaquenil Oral. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Plaquenil Side Effects Common, Severe, Long Term -. Aug 18, 2009 I thought that plaquenil was more processed by the kidneys than the liver and the problem you describe is what my gi doc calls "dumping" when the liver can't handle the med and acts like its poison and you get explosive diarrhea as your body tries to get rid of it. Hydroxychloroquine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away headache; dizziness; loss of appetite; nausea; diarrhea; stomach pain; vomiting; skin rash; If you experience any of the following symptoms, call your doctor immediately I suspect plaquenil for giving me some episodic diarrhea. I am 100 mg dose and take it with my supper. Did they happen to anyone else and did it eventually stop with the diarrhea side effect? It helps so much with the fatigue and pain. I have a sensitive stomach and perhaps I shouldn't have eaten that salad for lunch yesterday.