Chloroquine lysosome ph

Discussion in 'Trusted Online Pharmacy' started by starogil, 08-Mar-2020.

  1. collor XenForo Moderator

    Chloroquine lysosome ph


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    Chloroquine raises the pH in host-cell lysosomes, which interferes with viruses’ attempts to acidify the lysosomes, a prerequisite to formation of the autophagosomes that cells use to eat themselves. In the Cell Research paper, the researchers found that the drug was effective at inhibiting the virus as it was both entering and exiting cells. CQ is a weak base and therefore it can raise the pH of cellular compartments. This has led to the assumption that CQ blocks the autophagic flux through the same mechanism as BafA 1, which increases lysosomal pH and thus inhibits the activity of resident hydrolases 14 – 16. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

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    Chloroquine lysosome ph

    Chloroquine-treated cells with lysotracker staining?, Chloroquine inhibits autophagic flux by decreasing.

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  3. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes.

    • Inhibition of autophagy with bafilomycin and chloroquine..
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    Chloroquine is also a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body. The pK a for the quinoline nitrogen of chloroquine is 8.5, meaning it is about 10% deprotonated at physiological pH as calculated by the Henderson-Hasselbalch equation. This decreases to about 0.2% at a lysosomal pH of 4.6. Log D at the physiological pH of 7.4 was obtained experimentally from the plot of log D versus pH. This was compared with the calculated value of log D, obtained from Equation 2. Log D at the probable pH of the digestive vacuole or lysosome was calculated from log P by substituting pH 5.2 for 7.4 in Equation 2. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

     
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  6. Nikonov XenForo Moderator

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