These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Warfarin interaction with hydroxychloroquin Chloroquine sle mechanism Metabolism of chloroquine I've kinda noticed the same thing but I have a lactose intolerance. It wasn't as severe as it was when I was a child until I started Plaquenil. When I started Plaquenil almost 2 months ago I assumed the GI issues were a side effect and it would eventually go away but it hasn't. I'm going to bring it up to my rheumy when I see him. I have a problem. I was diagnosed on October 14, 2013 with UCTD. The Rheumatologist put me on Plaquenil. I started with just one pill per day because I sometimes have side effects from new drugs. After just 4 days on Plaquenil, I had severe stomach cramps, no appetite, GERD pain, diarrhea and a migraine. Hydroxychloroquine side effects may vary greatly from very mild side effects that go away with time to severe side effects like eye damage, ear damage, or heart problems. Some side effects may be experienced as the body adjusts to hydroxychloroquine but may diminish as the body becomes used to the drug. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Plaquenil side effects stomach pain Plaquenil Side Effects - GoodRx, Stomach cramps from Plaquenil - what to do? Lupus Forums. Chloroquine concentration to inhibit autophagyIs plaquenil an immunomodulator Abdominal pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA. Will you have Abdominal pain with Plaquenil - eHealthMe. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Will you have Chest pain with Plaquenil - eHealthMe. Yes, plaquenil is difficult to adjust first, but after the first year of treatment and side effects, the benefits outweigh the problems. So, stick with it. In my opinion, the plaque nil is keeping the immune system regulated and the pain and other symptoms described will reduce. Lupus is not an illness without pain or sacrifice, but, it’s. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints.